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Among these women, 85.7% received appropriate antenatal prophylaxis and 98.5% of eligible women received appropriate postnatal prophylaxis. Results: Antenatal administration was analyzed in 1868 pregnancies in eligible Rh-negative women. Logistic regression analysis was used to estimate the odds ratio and 95% confidence intervals of determinants of non-adherence to current recommendations for anti-D prophylaxis. We compared adherence to anti-D prophylaxis recommendations between our institution's physician-dependent antenatal approach and the protocol-based postpartum approach. Methods: We conducted a retrospective cohort study of all pregnancies recorded at the Royal Victoria Hospital between 20 to determine the rates of antenatal and postnatal prophylaxis in Rh(D)-negative women. The purpose of this study was to compare adherence to prophylaxis recommendations for antenatal and postnatal anti-D immunoglobulin administration. Abstract Objective: Although anti-D prophylaxis has greatly reduced the rate of Rh-immunization, there remain women who sensitize during or after pregnancy because of inadequate prophylaxis. Grunbaum ABenjamin AKoby RAbenhaim HA Koby LGrunbaum ABenjamin AKoby RAbenhaim HA Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal QC. Anti-d in rh(d)-negative pregnant women: are at-risk pregnancies and deliveries receiving appropriate prophylaxis ? Koby LKoby L, Grunbaum A, Benjamin A, Koby R, Abenhaim HA. DOENA HEMOLTICA PERINATAL Giovanni Fraga Lenza Slide 2 1.Incompatibilidade sangunea materno-fetal 2.Passagem do sangue fetal para circulao materna 3.Reconhecimento do Ag 4.Produo de Ac 5.Passagem dos Ac para circulao fetal 6.Ao dos Ac sobre as hemcias fetais 1.Incompatibilidade sangunea materno-fetal 2.Passagem do sangue fetal para circulao materna 3.Reconhecimento do Ag 4.Produo de Ac 5.Passagem dos Ac para circulao fetal 6.Ao dos Ac sobre as hemcias fetais Doena Hemoltica Perinatal Histria natural Slide 3 J Obstet Gynaecol Can.J Obstet Gynaecol Can.